Good morning. If someone is taking pharmaceuticals for sleep - Trazadone, 50mg , I am curious if they are able to enter the full sleep cycle. Does the drug inhibit Delta sleep? Does it affect the glymphatic system? They report 3 falling asleep more easily, but wake after 3 hours, and several times during the night. For the last few months, they have only managed a max of 5 hours. They wake feeling sluggish and tired. I have recommended sleep hygiene and a cup of chamomile. I don't know if incorporating passionflower will help or if anything will over ride the drug? There has been quite a bit of emotional turmoil / stress. She has a regular exercise program, and other modalities including talk therapy, massage, acupuncture. Thank you

Trazadone increases delta sleep, thus it increases lymphatic activity but significantly decreases REM sleep. Also the longer it is used the less effective it becomes.