Understanding the difference between SERMS & Modulators

By tyler in 18 Feb 2025 | 22:45
tyler

tyler

 Student
Posts: 26
Member since: 15 Nov 2023
I am trying to understand the difference between SERMS and hormonal " modulating" herbs. can you explain how something like shatavari might be considered a hormone modulator, even though it doesnt directly fill in an estrogen receptor site? would it work via the HPAG axis and indirectly impact estrogen? I have read that it might increase the sensitivity of estrogen receptor sites but that it does not fill them like a traditional SERM ( soy, red clover, kudzu) etc.
18 Feb 2025 | 22:45
0 Likes
Karla Parker

Karla Parker

 Instructor
Posts: 213
Member since: 16 Dec 2024
David said: The research on plant SERM’s is actually not as clear as one might think. They do not necessarily “fill” estrogen receptor sites, they act as competitive partial agonists . Different plant SERM’s seem to do somewhat different things such as the effects of lignan’s or isoflavones. As for Shatavari it works via the HPA axis, and as such seems to balance the pituitary (possibly FSH and LH), as well as other endocrine activity (this can include the ovaries, etc).
22 Feb 2025 | 01:12
0 Likes
tyler

tyler

 Student
Posts: 26
Member since: 15 Nov 2023
Thank you! Such a complex topic it seems. I appreciate this distinction.
26 Feb 2025 | 22:00
0 Likes

Report

Please describe about the report short and clearly.

Quick Links

More

Newsletter

Join our mailing list and stay up to date with the latest herbal goodness and David Winston's Center for Herbal Studies of Herbal Medicine news!

Contact

Lorem ipsum dolor sit amet consectetur. Vulputate consectetur integer ut platea

© 2025 David Winston's Center for Herbal Studies All rights reserved by Web Tech Crafts LLC

Your privacy matters

Cookies and similar technologies are used on our sites to personalize content and ads. You can find further details and change your personal settings below. By clicking OK, or by clicking any content on our sites, you agree to the use of these cookies and similar technologies.

GDPR

When you visit any of our websites, it may store or retrieve information on your browser, mostly in the form of cookies. This information might be about you, your preferences or your device and is mostly used to make the site work as you expect it to. The information does not usually directly identify you, but it can give you a more personalized web experience. Because we respect your right to privacy, you can choose not to allow some types of cookies. Click on the different category headings to find out more and manage your preferences. Please note, that blocking some types of cookies may impact your experience of the site and the services we are able to offer.

  • These cookies are necessary for our website to function properly and cannot be switched off in our systems. They are usually only set in response to actions made by you that amount to a request for services, such as setting your privacy preferences, logging in or filling in forms, or where they’re essential to providing you with a service you have requested. You cannot opt out of these cookies. You can set your browser to block or alert you about these cookies, but if you do, some parts of the site will not then work. These cookies do not store any personally identifiable information.
  • These cookies allow us to count visits and traffic sources so we can measure and improve the performance of our site. They help us to know which pages are the most and least popular and see how visitors move around the site, which helps us optimize your experience. All information these cookies collect is aggregated and therefore anonymous. If you do not allow these cookies we will not be able to use your data in this way.
  • These cookies enable the website to provide enhanced functionality and personalization. They may be set by us or by third-party providers whose services we have added to our pages. If you do not allow these cookies then some or all of these services may not function properly.
  • These cookies may be set through our site by our advertising partners. They may be used by those companies to build a profile of your interests and show you relevant adverts on other sites. They do not store directly personal information but are based on uniquely identifying your browser and internet device. If you do not allow these cookies, you will experience less targeted advertising.