David, This metaanalysis -- basically showed the best results w/ the study that used 600 mg IV x 3 wks. Then I believe there were only two other studies that met their incluson criteria. There did not appear to be in any increased benefit over 600 mg per day. There was also a very strong placebo effect (one could also argue an even stronger placebo effect by giving a person and IV! every day). The review also points out some interesting conflicts of interest -- most of studies done by same German group which is paid by the supp company. a company advisor also sat on the study advisory board. Where does your recommendation stand w/ ALA, and what dose? Also, I can't remember if you had a few herbs that you tended to put into formulas for diabetic peripheral neuropathy. I know everyone is different. Int J Endocrinol. 2012; 2012: 456279. Published online 2012 Jan 26. doi: 10.1155/2012/456279 PMCID: PMC3272801 PMID: 22331979 Alpha Lipoic Acid for Symptomatic Peripheral Neuropathy in Patients with Diabetes: A Meta-Analysis of Randomized Controlled Trials Gerritje S. Mijnhout, 1 ,* Boudewijn J. Kollen, 2 Alaa Alkhalaf, 1 , 3 , 4 Nanno Kleefstra, 3 , 4 , 5 and Henk J. G. Bilo 1 , 3 , 4

I use 250 mg BID of an alpha-lipoid acid from a company called Reliance (they are a private labeler and the product is usually sold by the store name). The product is a Japanese ALA and I get better results with it than other products I have tried. For diabetic neuropathy I also use herbs such as St John’s wort, Prickly Ash, Cinnamon twig (Gui Zhi) and the supplement PEA. Int J Endocrinol. 2012; 2012: 456279. Published online 2012 Jan 26. doi: 10.1155/2012/456279 PMCID: PMC3272801 PMID: 22331979 Alpha Lipoic Acid for Symptomatic Peripheral Neuropathy in Patients with Diabetes: A Meta-Analysis of Randomized Controlled Trials Gerritje S. Mijnhout, 1 ,* Boudewijn J. Kollen, 2 Alaa Alkhalaf, 1 , 3 , 4 Nanno Kleefstra, 3 , 4 , 5 and Henk J. G. Bilo 1 , 3 , 4