I have-not used pycnogenol, but have used DIM as part of an endometriosis protocol. Please remember we do not treat endometriosis, we treat a person who has endometriosis as well as many other issues. So we want to clear hormones via the liver and bowel (alteratives, cholagogues-m Oregon Grape root, ), normalize hormones (Chaste tree, Licorice), reduce inflammation, enhance circulation (Si Wu Tang), if stress is an issue then address it as well and relieve pain (Jamaica Dogwood, Cyperus, Corydalis).